Skin Histopathology of Diabetes Mellitus Rats Treated with Edible Nest Swiftlets (Aerodhramus fuciphagus) Ointment

The edible nest swiftlets are suspected to contain sialic acid that can increase the process of cell growth reduce formation scar tissue and accelerate wound healing. This study aimed determine effect optimal dosage ointment on skin histopathology diabetes mellitus rats suffered a scratch wound. used 25 male white rats, divided into 5 groups, all groups were treated with betadine intervention group 1 was vaseline only (control group), 2, 3, 4 (ENS) 10%, 20%, 30% concentration sanoskin as control positive. injured in back area given treatment according once day for 14 days. Skin taken make histopathologic preparations observation 0th, 7th, 14th parameters observed included number macrophages, neo-capillarization, fibroblasts. result showed macrophages group, ENS 3.8±5.019; 3.2±2.489; 1.84±2.387; 1.8±2.049 1.2±1.095. neocapillilization 1.28±1.673; 1.4±1.673; 2.8±1.778; 5.4±4.159; 15±30.773. conclusion there significant difference neocapillilization, density fibroblasts